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Abstract Background: Systemic arterial hypertension (SAH) and diabetes mellitus (DM) are grievances that are sensitive to the measures of promotion and prevention; however, they interfere with the quality of life (QL). Objective: The aim of this study was to evaluate the QL in elderly people with SAH and DM and compare their impact on the QL of these groups. Method: It was used as a methodology a sectional, domiciliary-based study in which the data were collected using a questionnaire with sociodemographic information, clinical and QL, through the WhoQol-Bref and analyzed in the SPSS software. Results: A total of 498 elderly people were evaluated, of whom 9.64% had DM, 53.21% had SAH, and 37.15% had both diseases. The majority were women (66.9%), from 60 to 69 years old (49.4%), mixed race (61.6%), from 9 to 11 years of study (53%), family budget under two minimum wages (48.6%), married (52.8%), and using five or more medications (18.9%). There was a difference among the groups (SAH, QL, or both) in the physical domain (p=0.003) and in the social relationships (p=0.017). In the physical domain, the post hoc tests showed better QL in SAH groups compared to the others. Conclusions: The patients with SAH showed better general QL. The psychological domain was the least affected and the environment domain was the most affected.
Resumo Introdução: Hipertensão (HAS) e diabetes mellitus (DM) são agravos cujo controle é sensível a medidas de promoção e prevenção, no entanto interferem na qualidade de vida (QV). Objetivos: Avaliar a QV em idosos com HAS e DM e comparar o impacto na QV entre esses grupos. Método: Utilizou-se como metodologia um estudo seccional de base domiciliar, cujos dados foram coletados por meio de questionário com informações sociodemográficas, clínicas e de QV, por meio do WhoQol-Bref, e analisados por meio do software SPSS. Resultados: Foram avaliados 498 idosos, 9,64% com DM, 53,21% com HAS e 37,15% com ambos os agravos. A maioria era mulher (66,9%) entre 60 e 69 anos (49,4%), parda (61,6%), com nove a doze anos de estudo (53%), renda familiar abaixo de dois salários mínimos (48,6%), casada (52,8%) e 18,9% era polifármaca. Houve diferença entre os grupos (HAS, DM ou ambos) no domínio físico (p=0,003) e relações sociais (p=0,017). No domínio físico os testes post hoc apontaram melhor QV no grupo HAS em relação aos demais (p<0,05). Conclusões: Os pacientes com HAS apresentaram melhor QV geral. O domínio psicológico foi o menos afetado, e o domínio meio ambiente, o que mais sofreu impacto.
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem cells. Here we use bio-orthogonal proteome labeling for detecting in vivo proteins present only in transplanted myoblasts, but not in host tissue, and proteins exclusive to one young mouse and transferred during parabiosis to its old partner. We use a transgenic mouse strain that ubiquitously expresses a modified tRNA methionine synthase, metRS, which preferentially incorporates the methionine surrogate azido-nor-leucine (ANL) into newly generated proteins. Using click chemistry and a modified antibody array to detect ANL-labeled proteins, we identify several 'young' systemic factors in old regenerating muscle of the heterochronic parabiotic partners. Our approach enables the selective profiling of mammalian proteomes in mixed biological environments such as cell and tissue transplantation, apheresis or parabiosis.Clarifying the source of proteins in mixed biological environments, such as after transplantation or parabiosis, remains a challenge. Here, the authors address this need with a mouse strain that incorporates a methionine derivate into proteins, allowing for their detection using click chemistry and antibody arrays.
